Rejuran
Hydrate & Restore
Rejuran (also known as PDRN therapy) is a Korean skin booster made from purified polynucleotides derived from salmon DNA. PDRN (polydeoxyribonucleotide) molecules are biologically similar to human DNA and work by activating adenosine receptors in skin cells — stimulating cellular repair, collagen production, and restoration of the skin's natural regenerative capacity. It is one of the most popular skin rejuvenation treatments in Korea.
BEFORE
AFTER
How it works
Rejuran is injected into the dermis via a series of micro-injections (papule technique) across the treatment area. PDRN molecules bind to adenosine A2A receptors on fibroblasts and keratinocytes, promoting cell proliferation, collagen synthesis, and anti-inflammatory signaling. Over 4–6 weeks, the skin's regenerative mechanisms are restored — improving elasticity, hydration, and texture from the cellular level.
Who is it for?
Dehydrated, thin, or depleted skin; skin that has lost elasticity or bounce; fine surface lines; dull, fatigued-looking skin; patients seeking skin-quality improvement rather than volume; those wanting a natural, gradual restoration of skin health.
Who is it not for?
Fish or seafood allergy (PDRN is salmon-derived — discuss with provider); pregnancy; active infection in treatment area; bleeding disorders; patients on certain blood thinners.
Session Time
45–60 min (including numbing)
Down Time
Mild redness and papules 24–48 hrs (normal)
Results?
4–6 weeks
Peak Results
Month 2–3 (after series)
How long does it last?
6–12 months
How many sessions?
3–4 (spaced 2–4 weeks), then maintenance every 6 months
Build Your Protocol
Your skin has more than one concern. Your protocol should too.
What makes Rejuran different from HA fillers?
Rejuran doesn't add volume — it restores the skin's biological regenerative capacity. Rather than filling space, it stimulates the skin to produce more collagen, improve hydration retention, and function better at the cellular level. The result is improved skin quality, not volume.
Is it safe if I eat salmon?
PDRN is highly purified polynucleotide DNA — not a protein allergen. However, if you have a known severe seafood or fish allergy, please inform us at your consultation so we can assess appropriately.
Can Rejuran be combined with other treatments?
Yes — Rejuran pairs beautifully with OligioX, neurotoxin, and Juvelook. It can be done on the same day as non-invasive treatments. For energy-based treatments (Potenza, laser), we typically space them out by 1–2 weeks.